Tobanka Qof ee ugu Sarreysa Sayniska:

Yunlong Cao ee jaamacadda Peking ayaa loo magacaabay cilmi-baaris cusub oo coronavirus ah

15ka Diseembar 2022, Dabeecadda waxay ku dhawaaqday 10-keeda Dabeecadda, liiska tobanka qof ee qayb ka ahaa dhacdooyinka sayniska ee ugu waaweyn sanadka, oo sheekadoodu ay bixiso aragti gaar ah oo ku saabsan qaar ka mid ah dhacdooyinka sayniska ee ugu muhiimsan ee sanadkan aan caadiga ahayn.

Sannadkii xasarado iyo daahfurnaan xiiso leh, Dabeecadda waxay toban qof ka dooratay cirbixiyeennada kuwaas oo naga caawiyay inaan fahanno jiritaanka caalamka ugu fog, cilmi-baarayaasha udub-dhexaadka u ahaa cudurrada faafa ee Crown-ka cusub iyo cudurka daanyeerka, dhakhaatiirta qalliinka ee jebiyey xadka xubinta taranka. , ayuu yidhi Rich Monastersky, oo ah tifaftiraha guud ee Tilmaamaha Dabeecadda.

Yunlong Cao waxa uu ka socdaa Xarunta Innovation Frontier Biomedical Frontier (BIOPIC) ee Jaamacadda Peking. Dr. Cao waxa uu ka qalin jabiyay jaamacadda Zhejiang shahaado jaamacadeed oo fiisigis ah,waxana uu PhD ka qaatay jaamacadda Harvard qaybteeda Kimistariga iyo Kiimikada Bayoloji ee hoos taga Xiaoliang Xie,waxana uu wakhtigan ka yahay xidhiidhiye cilmi-baadhiseed oo ka tirsan xarunta hal-abuurka ee Biomedical Frontier innovation ee jaamacadda Peking. Yunlong Cao waxa uu diiradda saarayay horumarinta tignoolajiyada isku xigxiga hal unug, cilmi-baadhistiisuna waxa ay gacan ka gaysatay la socodka horumarka coronavirus-ka cusub oo uu saadaaliyo qaar ka mid ah isbeddellada horseeda abuurista noocyo cusub oo mutant ah.

18ka Meey 2020, Xiaoliang Xie/Yunlong Cao et al. ayaa lagu daabacay warqad joornaalka Cell cinwaankeedu yahay: "Awoodda ka-hortagga unugyada difaaca jirka ee ka dhanka ah SARS-CoV-2 oo lagu aqoonsaday taxane hal unug ah oo sarreeya ee unugyada B ee bukaannada." Warqadda cilmi-baarista.

Daraasaddan ayaa ka warbixisay natiijooyinka coronavirus-ka cusub (SARS-CoV-2) ee ka-hortagga shaashadda antibody-ka, kaas oo adeegsadey hal unug RNA iyo VDJ isku-xiran si loo aqoonsado 14 si adag u baabi'inaya unugyada difaaca jirka ee ka badan 8500 antigen-ku xiran IgG1 60 qof oo laga helay COVID-19.

Daraasadani waxay muujinaysaa markii ugu horeysay in isku xigxiga hal unug oo sareeya si toos ah loogu isticmaali karo helitaanka daroogada waxayna faa'iido u leedahay inay noqoto mid degdeg ah oo wax ku ool ah, kaas oo ballan qaadaya inuu wax ka beddelo habka dadku u baadho ka hortagga unugyada difaaca ee fayraska faafa.

17ka Juun 2022, Xiaoliang Xie/Yunlong Cao et al. daabacay warqad cinwaankeedu yahay: BA.2.12.1, BA.4 iyo BA.5 ka baxsanayaan unugyada difaaca jirka ee uu keeno caabuqa Omicron ee joornaalka Nature.

Daraasadani waxay ogaatay in noocyada cusub ee noocyada cusub ee Omicron mutant BA.2.12.1, BA.4 iyo BA.5 ay muujiyeen kororka baxsashada difaaca iyo dhexdhexaadinta weyn ee baxsashada plasma ee soo kabsaday Omicron BA.1-bukaannada.

Natiijooyinkani waxay soo jeedinayaan in tallaalka Omicron-ku-saleysan BA.1 laga yaabo inuusan hadda ku habboonayn xoojinta xaaladda tallaalka ee hadda jirta iyo in unugyada difaaca jirka aysan bixin doonin difaac ballaaran oo ka dhan ah nooca cusub ee mutant. Intaa waxaa dheer, difaaca lo'da ee loo maro caabuqa Omicron aad ayay u adag tahay in la gaaro sababtoo ah ifafaalaha 'immunogenic' ee coronaviruses cusub iyo horumarka degdega ah ee goobaha badbaadada difaaca.

30kii Oktoobar 2022, kooxda Xiaoliang Xie/Yunlong Cao ayaa daabacday warqad cilmi baaris ah oo ciwaankeedu yahay: Xasaanadda kaftanka ee SARS-CoV-2 ee la dahaadhay waxay kicisaa kobaca Omicron RBD isku-dhafka ah ee bioRxiv preprint.

Daraasadani waxay soo jeedinaysaa in faa'iidada XBB ee BQ.1 ay sabab u tahay qayb ka mid ah isbeddelada ka baxsan qaybta receptor binding domain (RBD) ee spinosin, in XBB uu sidoo kale leeyahay isbeddello qaybo ka mid ah genome-ga oo dhigaya N-terminal structural domain (NTD). ) ee spinosin-ka, iyo in XBB uu awoodo in uu ka baxsado ka-hortagga unugyada difaaca jirka ee NTD, kaas oo u oggolaan kara in uu qaadsiiyo dadka difaaca BQ.1 iyo noocyada hoose ee la xiriira. Si kastaba ha ahaatee, waxaa xusid mudan in isbeddellada gobolka NTD ay ku dhacaan BQ.1 heer aad u degdeg ah. Isbeddelladani waxay si weyn u kordhiyaan awoodda kala duwanaanshahan si ay uga baxsadaan unugyada difaaca jirka ee uu soo saaray tallaalka iyo caabuqyada hore.

Dr. Yunlong Cao ayaa sheegay in laga yaabo in ay jiraan wax ka hortag ah oo ka dhan ah XBB haddii uu ku dhaco BQ.1, laakiin loo baahan yahay cilmi baaris dheeraad ah si loo helo caddaynta arrintan.

Marka lagu daro Yunlong Cao, laba qof oo kale ayaa sameeyay liiska wax ku biirintooda aadka u wanaagsan ee arrimaha caafimaadka bulshada, Lisa McCorkell iyo Dimie Ogoina.

Lisa McCorkell waa cilmi-baare leh Long COVID iyo xubin aasaasi ah oo ka tirsan Iskaashatada Cilmi-baarista ee Bukaan-socodka, waxay gacan ka geysatay kor u qaadista wacyiga iyo maalgelinta cilmi-baarista cudurka.

Dimie Ogoina waa dhaqtar cudurada faafa oo ka tirsan jaamacada Niger Delta ee Nigeria shaqadiisa ku saabsan cudurka daanyeerka ee Nigeria ayaa bixiyay macluumaad muhiim ah oo ku aadan dagaalka ka dhanka ah cudurka daanyeerka.

10kii Janaayo 2022, Jaamacadda Maryland School of Medicine ayaa ku dhawaaqday in wadnihii doofaarka ee ugu horreeyay ee lagu geliyo qof nool, markii 57-jir bukaan wadnaha ah David Bennett uu helay tallaalka wadnaha doofaarka ee la tafatiray si uu naftiisa u badbaadiyo. .

Inkasta oo wadnaha doofaarku uu kaliya ku kordhiyay nolosha David Bennett laba bilood, waxay ahayd guul weyn iyo horumar taariikhi ah oo ku saabsan beerta xenotransplantation. Muhammad Mohiuddin, dhakhtarka qalliinka ee hogaaminayay kooxda dhamaystirtay beeritaanka bini'aadamka ee wadnaha doofaarka ee hiddo-wadaha, ayaa shaki la'aan lagu magacaabay liiska 10ka qof ee ugu sarreeya ee dabeecadda.

Dhawr kale ayaa loo doortay horumarinta guulo saynis oo aan caadi ahayn iyo horumarro siyaasadeed oo muhiim ah, oo ay ku jirto cirbixiyeen Jane Rigby oo ka tirsan Xarunta Goddard Space Center ee NASA, oo door muhiim ah ka ciyaartay hamigii Telescope Space Webb ee ahaa in telescope-ka la geliyo meel sare oo uu si sax ah u shaqeeyo, iyada oo qaadanaysa awoodda aadanaha ee sahaminta. caalamka heer cusub iyo heer sare. alondra Nelson, isagoo ah Ku-simaha Agaasimaha Siyaasadda Sayniska iyo Tignoolajiyada ee Xafiiska Sayniska iyo Tignoolajiyada, wuxuu ka caawiyay maamulka Madaxweyne Biden inay horumariyaan waxyaabo muhiim ah oo ajandaha sayniska ah, oo ay ku jiraan siyaasad ku saabsan daacadnimada sayniska iyo tilmaamaha cusub ee sayniska furan. Diana Greene Foster, cilmi-baare ilmo iska soo ridid ​​ah iyo xisaabiye ka tirsan Jaamacadda California, San Francisco, ayaa bixisay xog muhiim ah oo ku saabsan saameynta la filayo ee go'aanka Maxkamadda Sare ee Mareykanka ee lagu burinayo ilaalinta sharciga ee xuquuqda ilmo soo rididda.

Waxa kale oo jira magacyo ku jira liiska tobanka ugu sarreeya sannadkan kuwaas oo khuseeya horumarinta isbeddelka cimilada iyo dhibaatooyinka kale ee caalamiga ah. Waxay kala yihiin: António Guterres, Xoghayaha Guud ee Qaramada Midoobay, Saleemul Huq, Agaasimaha Xarunta Caalamiga ah ee Isbeddelka Cimilada iyo Horumarinta ee Dhaka, Bangladesh, iyo Svitlana Krakovska, oo ah madaxa ergada Yukreeniyaan ee Guddiga Qaramada Midoobay ee Isbeddelka Cimilada. IPCC).